Altered dorsal premotor–motor interhemispheric pathway activity in focal arm dystonia
Identifieur interne : 002A11 ( Main/Exploration ); précédent : 002A10; suivant : 002A12Altered dorsal premotor–motor interhemispheric pathway activity in focal arm dystonia
Auteurs : Giacomo Koch [Royaume-Uni, Italie] ; Susanne Schneider [Royaume-Uni] ; Tobias B Umer [Allemagne] ; Michele Franca [Royaume-Uni] ; Alexander Münchau [Allemagne] ; Binith Cheeran [Royaume-Uni] ; Miguel Fernandez Del Olmo [Royaume-Uni, Espagne] ; Carla Cordivari [Royaume-Uni] ; Elisabeth Rounis [Royaume-Uni] ; Carlo Caltagirone [Italie] ; Kailash Bhatia [Royaume-Uni] ; John C. Rothwell [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-04-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Arm (physiopathology), Dystonia, Dystonic Disorders (diagnosis), Dystonic Disorders (physiopathology), Electrodiagnosis, Evoked Potentials, Motor, Female, Frontal Lobe (physiopathology), Humans, Male, Middle Aged, Motor Cortex (physiopathology), Motor pathway, Nervous system diseases, Neural Inhibition, Neural Pathways (physiopathology), Paired stimulation, Premotor cortex, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, connectivity, cortical inhibition, dystonia, paired transcranial magnetic stimulation, premotor cortex, rTMS, transcallosal inhibition.
- MESH :
- diagnosis : Dystonic Disorders.
- physiopathology : Arm, Dystonic Disorders, Frontal Lobe, Motor Cortex, Neural Pathways.
- Adult, Aged, Aged, 80 and over, Electrodiagnosis, Evoked Potentials, Motor, Female, Humans, Male, Middle Aged, Neural Inhibition, Transcranial Magnetic Stimulation.
Abstract
Given the possible role of dorsal premotor cortex (PMd) in the pathophysiology of dystonia, we used transcranial magnetic stimulation (TMS) methods to study PMd and PMd–primary motor cortex (M1) interactions in patients with focal arm dystonia. Here, we tested the connectivity between left PMd and right M1 as well as the intracortical excitability of PMd in 11 right‐handed patients with focal arm/hand dystonia and nine age‐matched healthy controls. The results showed that excitability of the inhibitory connection between PMd and M1 was reduced in patients, but there was no significant difference to healthy subjects in the excitability of the facilitatory connection. A triple stimulation technique in which pairs of TMS pulses are given over PMd and their interaction measured in terms of the effect on the baseline PMd‐M1 connection failed to reveal the usual pattern of interaction between the pairs of PMd stimuli. Indeed, the results in patients were similar to those seen in a group of young healthy subjects after the excitability of PMd had been changed by pretreatment with high‐frequency rTMS. We suggest that reduced transcallosal inhibition from the PMd may be involved in the altered pattern of abnormal muscle contractions of agonists and antagonists (overflow). © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21881
Affiliations:
- Allemagne, Espagne, Italie, Royaume-Uni
- Angleterre, Grand Londres, Hambourg, Latium
- Hambourg, Londres, Rome
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Le document en format XML
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uniqKey="Schneider S" first="Susanne" last="Schneider">Susanne Schneider</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Centre Hamburg‐Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Franca, Michele" sort="Franca, Michele" uniqKey="Franca M" first="Michele" last="Franca">Michele Franca</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Centre Hamburg‐Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" 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University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>INEF Galicia, Institute of Physical Education and Sport, La Coruña</wicri:regionArea><wicri:noRegion>La Coruña</wicri:noRegion></affiliation></author><author><name sortKey="Cordivari, Carla" sort="Cordivari, Carla" uniqKey="Cordivari C" first="Carla" last="Cordivari">Carla Cordivari</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rounis, Elisabeth" sort="Rounis, Elisabeth" uniqKey="Rounis E" first="Elisabeth" last="Rounis">Elisabeth Rounis</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Caltagirone, Carlo" sort="Caltagirone, Carlo" uniqKey="Caltagirone C" first="Carlo" last="Caltagirone">Carlo Caltagirone</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS, Via Ardeatina, 306, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata, Via Montpellier 1, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bhatia, Kailash" sort="Bhatia, Kailash" uniqKey="Bhatia K" first="Kailash" last="Bhatia">Kailash Bhatia</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-04-15">2008-04-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="660">660</biblScope><biblScope unit="page" to="668">668</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">4319D02CEE23B889480F8EC1CD7E39299CAAFCA3</idno><idno type="DOI">10.1002/mds.21881</idno><idno type="ArticleID">MDS21881</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Arm (physiopathology)</term><term>Dystonia</term><term>Dystonic Disorders (diagnosis)</term><term>Dystonic Disorders (physiopathology)</term><term>Electrodiagnosis</term><term>Evoked Potentials, Motor</term><term>Female</term><term>Frontal Lobe (physiopathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Motor pathway</term><term>Nervous system diseases</term><term>Neural Inhibition</term><term>Neural Pathways (physiopathology)</term><term>Paired stimulation</term><term>Premotor cortex</term><term>Transcranial Magnetic Stimulation</term><term>Transcranial magnetic stimulation</term><term>connectivity</term><term>cortical inhibition</term><term>dystonia</term><term>paired transcranial magnetic stimulation</term><term>premotor cortex</term><term>rTMS</term><term>transcallosal inhibition</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arm</term><term>Dystonic Disorders</term><term>Frontal Lobe</term><term>Motor Cortex</term><term>Neural Pathways</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Electrodiagnosis</term><term>Evoked Potentials, Motor</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neural Inhibition</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cortex prémoteur</term><term>Dystonie</term><term>Pathologie du système nerveux</term><term>Stimulation couplée</term><term>Stimulation magnétique transcrânienne</term><term>Voie motrice</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Given the possible role of dorsal premotor cortex (PMd) in the pathophysiology of dystonia, we used transcranial magnetic stimulation (TMS) methods to study PMd and PMd–primary motor cortex (M1) interactions in patients with focal arm dystonia. Here, we tested the connectivity between left PMd and right M1 as well as the intracortical excitability of PMd in 11 right‐handed patients with focal arm/hand dystonia and nine age‐matched healthy controls. The results showed that excitability of the inhibitory connection between PMd and M1 was reduced in patients, but there was no significant difference to healthy subjects in the excitability of the facilitatory connection. A triple stimulation technique in which pairs of TMS pulses are given over PMd and their interaction measured in terms of the effect on the baseline PMd‐M1 connection failed to reveal the usual pattern of interaction between the pairs of PMd stimuli. Indeed, the results in patients were similar to those seen in a group of young healthy subjects after the excitability of PMd had been changed by pretreatment with high‐frequency rTMS. We suggest that reduced transcallosal inhibition from the PMd may be involved in the altered pattern of abnormal muscle contractions of agonists and antagonists (overflow). © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Espagne</li><li>Italie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Hambourg</li><li>Latium</li></region><settlement><li>Hambourg</li><li>Londres</li><li>Rome</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Koch, Giacomo" sort="Koch, Giacomo" uniqKey="Koch G" first="Giacomo" last="Koch">Giacomo Koch</name></region><name sortKey="Bhatia, Kailash" sort="Bhatia, Kailash" uniqKey="Bhatia K" first="Kailash" last="Bhatia">Kailash Bhatia</name><name sortKey="Cheeran, Binith" sort="Cheeran, Binith" uniqKey="Cheeran B" first="Binith" last="Cheeran">Binith Cheeran</name><name sortKey="Cordivari, Carla" sort="Cordivari, Carla" uniqKey="Cordivari C" first="Carla" last="Cordivari">Carla Cordivari</name><name sortKey="Fernandez Del Olmo, Miguel" sort="Fernandez Del Olmo, Miguel" uniqKey="Fernandez Del Olmo M" first="Miguel" last="Fernandez Del Olmo">Miguel Fernandez Del Olmo</name><name sortKey="Franca, Michele" sort="Franca, Michele" uniqKey="Franca M" first="Michele" last="Franca">Michele Franca</name><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name><name sortKey="Rounis, Elisabeth" sort="Rounis, Elisabeth" uniqKey="Rounis E" first="Elisabeth" last="Rounis">Elisabeth Rounis</name><name sortKey="Schneider, Susanne" sort="Schneider, Susanne" uniqKey="Schneider S" first="Susanne" last="Schneider">Susanne Schneider</name></country><country name="Italie"><region name="Latium"><name sortKey="Koch, Giacomo" sort="Koch, Giacomo" uniqKey="Koch G" first="Giacomo" last="Koch">Giacomo Koch</name></region><name sortKey="Caltagirone, Carlo" sort="Caltagirone, Carlo" uniqKey="Caltagirone C" first="Carlo" last="Caltagirone">Carlo Caltagirone</name><name sortKey="Caltagirone, Carlo" sort="Caltagirone, Carlo" uniqKey="Caltagirone C" first="Carlo" last="Caltagirone">Carlo Caltagirone</name><name sortKey="Koch, Giacomo" sort="Koch, Giacomo" uniqKey="Koch G" first="Giacomo" last="Koch">Giacomo Koch</name></country><country name="Allemagne"><region name="Hambourg"><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name></region><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name></country><country name="Espagne"><noRegion><name sortKey="Fernandez Del Olmo, Miguel" sort="Fernandez Del Olmo, Miguel" uniqKey="Fernandez Del Olmo M" first="Miguel" last="Fernandez Del Olmo">Miguel Fernandez Del Olmo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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